Genomics and Diabetes Unit

Cardiovascular Area

Identify genetic and environmental factors involved in the development of type 2 diabetes and related diseases

Identify alterations of methylation and hydroxymethylation in relation to the development of type 2 diabetes and its potential use as biomarkers

Identify genetic causes of rare diseases: Abeta, ATA and hereditary forms of hypercholesterolemias not caused by known genes

Study of environmental factors involved in the development of diseases of high cardiovascular risk, especially type 2 diabetes and associated organic damage

Development of fast and easy procedures for SARS-CoV2 (COVID19) detection and characterization (including the analysis of the main human genetic variations involved in COVID19)

Coordinator
Dr. Felipe Javier Chaves Martínez
felipe.chaves@uv.es

RESEARCHERS
Leading, R4

Felipe Javier Chaves Martínez    

Established, R3

Ana Bárbara García García

Recognised/Emerging, R2

Luis Álvarez Fernández

First Stage, R1

Celeste Moya Valera
Fran Lara Hernández

STAFF
Collaborating Researchers
Nurse
Technicians
Administrative assistant
Publications
Association between exposure to air pollution and blood lipids in the general population of Spain. Valdés S, Doulatram-Gamgaram V, Maldonado-Araque C, Garcia-Escobar E, Garcia-Serrano S, Oualla-Bachiri W, Garcia-Vivanco M, Garrido J, Gil V, Martin-Llorente F, Calle-Pascual A, Castaño L, Delgado E, Menéndez E, Franch-Nadal J, Gaztambide S, Girbés J, Chaves F, Galán-García J, Aguilera-Venegas G, Vallvé J, Amigó N, Guardiola M, Ribalta J, Rojo-Martínez G. European Journal of Clinical Investigation. 2023 Oct 5:e14101. doi: 10.1111/eci.14101. PMID: 37795744

Corrigendum to Genetic interaction in the association between oxidative stress and diabetes in the Spanish population [Free Radic. Biol. Med. 205 (2023) 62-68]. Melero R, Quiroz-Rodríguez ME, Lara-Hernández F, Redón J, Sáez G, Briongos-Figuero LS, Abadía-Otero J, Martín-Escudero JC, Chaves FJ, Ayala G, García-García AB. Free Radical Biology & Medicine. 2023 Jul 22;207:181-182. doi: 10.1016/j.freeradbiomed.2023.07.017. PMID: 37487450

Cross-sectional association between severe periodontitis and diabetes mellitus: a nation-wide cohort study. Montero E, Bujaldón R, Montanya E, Calle-Pascual A, Rojo-Martínez G, Castaño L, Franch-Nadal J, Delgado E, Chaves F, Alonso B, Sanz M, Herrera D. Journal of Clinical Periodontology. 2023 Dec 23. doi: 10.1111/jcpe.13937. PMID: 38140803

Dynamics of Human Anelloviruses in plasma and clinical outcomes following kidney transplantation. Forque L, Fernandez-Ruiz M, Albert E, Gimenez E, Monzo C, Chaves J, Redondo N, Rodriguez-Goncer I, Ruiz-Merlo T, Parra P, Andres A, Aguado JM, Navarro D. Transplantation. 2023 Feb 1;107(2):511-520. doi: 10.1097/TP.0000000000004292. PMID: 36042550

Genetic interaction in the association between oxidative stress and diabetes in the Spanish population. Melero R, Quiroz-Rodriguez M, Lara-Hernandez F, Redon J, Saez G, Briongos-Figuero L, Abadia-Otero J, Martin-Escudero J, Chaves F, Ayala G, Garcia-Garcia A. Free Radical Biology & Medicine. 2023 Jun 1;205:62-68. doi: 10.1016/j.freeradbiomed.2023.05.030. PMID: 37268047

High miR-126-3p levels associated with cardiovascular events in a general population. Martinez-Arroyo O, Ortega A, Flores-Chova A, Sanchez-Garcia B, Garcia-Garcia A, Chaves F, Martin-Escudero J, Forner M, Redon J, Cortes R. European Journal of Internal Medicine. 2023 Jul;113:49-56. doi: 10.1016/j.ejim.2023.04.013. PMID: 37080818

Metabolomic patterns, redox-related genes and metals, and bone fragility endpoints in the Hortega Study. Galvez-Fernandez M, Rodriguez-Hernandez Z, Grau-Perez M, Chaves F, Garcia-Garcia A, Amigo N, Monleon D, Garcia-Barrera T, Gomez-Ariza J, Briongos-Figuero L, Perez-Castrillon J, Redon J, Tellez-Plaza M, Martin-Escudero J. Free Radical Biology & Medicine. 2023 Jan;194:52-61. doi: 10.1016/j.freeradbiomed.2022.11.007. PMID: 36370960

Molecular research on genes involved in metabolic diseases. Lara-Hernandez F, Alvarez L, Chaves J, Garcia-Garcia A. Biomedicines. 2023 Jun 9;11(6):1671. doi: 10.3390/biomedicines11061671. PMID: 37371766

A very rare variant in SREBF2, a possible cause of hypercholesterolemia and increased glycemic levels. Garcia-Garcia A, Martinez-Hervas S, Vernia S, Ivorra C, Pulido I, Martin-Escudero J, Casado M, Carretero J, Real J, Chaves F. Biomedicines. 2022 May 19;10(5):1178. doi: 10.3390/biomedicines10051178. PMID: 35625914

Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study). Valdes S, Doulatram-Gamgaram V, Maldonado-Araque C, Lago-Sampedro A, Garcia-Escobar E, Garcia-Serrano S, Garcia-Vivanco M, Juan L, Theobald M, Gil V, Martin-Llorente F, Ocon P, Calle-Pascual A, Castano L, Delgado E, Menendez E, Franch-Nadal J, Gaztambide S, Girbes J, Chaves F, Galan-Garcia J, Aguilera-Venegas G, Gutierrez-Repiso C, Fernandez-Garcia J, Colomo N, Soriguer F, Garcia-Fuentes E, Rojo-Martinez G. Environmental Health. 2022 Aug 17;21(1):76. doi: 10.1186/s12940-022-00889-1. PMID: 35978396

An all-in-one point-of-care testing device for multiplexed detection of respiratory infections. Teixeira W, Pallas-Tamarit Y, Juste-Dolz A, Sena-Torralba A, Gozalbo-Rovira R, Rodriguez-Diaz J, Navarro D, Carrascosa J, Gimenez-Romero D, Maquieira A, Morais S. Biosensors & Bioelectronics. 2022 Jun 8;213:114454. doi: 10.1016/j.bios.2022.114454. PMID: 35696866

Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega Follow-up Study. Usategui-Martin R, Perez-Castrillon J, Mansego M, Lara-Hernandez F, Manzano I, Briongos L, Abadia-Otero J, Martin-Vallejo J, Garcia-Garcia A, Martin-Escudero J, Chaves F. Gene. 2022 Jan 30;809:146036. doi: 10.1016/j.gene.2021.146036. PMID: 34688818

Combined kinetic analysis of SARS-CoV-2 RNAemia, N-antigenemia and virus-specific antibodies in critically ill adult COVID-19 patients. Costa R, Alberola J, Olea B, Gozalbo-Rovira R, Gimenez E, Cuevas-Ferrando E, Torres I, Albert E, Carbonell N, Ferreres J, Sanchez G, Rodriguez-Diaz J, Blasco M, Navarro D. Scientific Reports. 2022 May 18;12(1):8273. doi: 10.1038/s41598-022-12461-5. PMID: 35585163

Correction: The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: the case of the spike A222V mutation. Ginex T, Marco-Marín C, Wieczór M, Mata CP, Krieger J, Ruiz-Rodriguez P, López-Redondo ML, Francés-Gómez C, Melero R, Sánchez-Sorzano CÓ, Martínez M, Gougeard N, Forcada-Nadal A, Zamora-Caballero S, Gozalbo-Rovira R, Sanz-Frasquet C, Arranz R, Bravo J, Rubio V, Marina A, Geller R, Comas I, Gil C, Coscolla M, Orozco M, Llácer JL, Carazo JM. PLoS Pathogens. 2022 Nov 23;18(11):e1010995. doi: 10.1371/journal.ppat.1010995. PMID: 36417341

Developing a simple and practical decision model to predict the risk of incident type 2 diabetes among the general population: The Di@bet.es Study. Martinez-Hervas S, Morales-Suarez-Varela MM, Andres-Blasco I, Lara-Hernandez F, Peraita-Costa I, Real JT, Garcia-Garcia AB, Chaves FJ. European Journal of Internal Medicine. 2022 Aug;102:80-87. doi: 10.1016/j.ejim.2022.05.005. PMID: 35570127

Gene-environment interaction analysis of redox-related metals and genetic variants with plasma metabolic patterns in a general population from Spain: the Hortega Study. Galvez-Fernandez M, Sanchez-Saez F, Domingo-Relloso A, Rodriguez-Hernandez Z, Tarazona S, Gonzalez-Marrachelli V, Grau-Perez M, Morales-Tatay J, Amigo N, Garcia-Barrera T, Gomez-Ariza J, Chaves F, Garcia-Garcia A, Melero R, Tellez-Plaza M, Martin-Escudero J, Redon J, Monleon D. Redox Biology. 2022 Jun;52:102314. doi: 10.1016/j.redox.2022.102314. PMID: 35460952

Genetic variants in obesity-related genes and the risk of osteoporotic fracture. The Hortega Follow-up Study. Usategui-Martin R, Perez-Castrillon J, Briongos-Figuero L, Abadia-Otero J, Lara-Hernandez F, Garcia-Sorribes S, Martin-Vallejo J, Garcia-Garcia A, Chaves F, Martin-Escudero J. Frontiers in Bioscience-Landmark. 2022 Jan 18;27(1):32. doi: 10.31083/j.fbl2701032. PMID: 35090337

Infant gut microbial metagenome mining of alpha-l-fucosidases with activity on fucosylated human milk oligosaccharides and glycoconjugates. Moya-Gonzalvez E, Pena-Gil N, Rubio-del-Campo A, Coll-Marques J, Gozalbo-Rovira R, Monedero V, Rodriguez-Diaz J, Yebra M. Microbiology Spectrum. 2022 Aug 31;10(4):e0177522. doi: 10.1128/spectrum.01775-22. PMID: 35943155

Recombinant noroviruses circulating in Spain from 2016 to 2020 and proposal of two novel genotypes within genogroup I. Navarro-Lleó N, Santiso-Bellón C, Vila-Vicent S, Carmona-Vicente N, Gozalbo-Rovira R, Cárcamo-Calvo R, Rodríguez-Díaz J, Buesa J. Microbiology Spectrum. 2022 Aug 31;10(4):e0250521. doi: 10.1128/spectrum.02505-21. PMID: 35862999

Replication of human norovirus in mice after antibiotic-mediated intestinal bacteria depletion. Santiso-Bellon C, Gozalbo-Rovira R, Buesa J, Rubio-Del-Campo A, Pena-Gil N, Navarro-Lleo N, Carcamo-Calvo R, Yebra MJ, Monedero V, Rodriguez-Diaz J. International Journal of Molecular Sciences. 2022 Sep 13;23(18):10643. doi: 10.3390/ijms231810643. PMID: 36142552

SARS-CoV-2 N-antigenemia in critically ill adult COVID-19 patients: frequency and association with inflammatory and tissue-damage biomarkers. Olea B, Albert E, Torres I, Gozalbo-Rovira R, Carbonell N, Ferreres J, Poujois S, Costa R, Colomina J, Rodriguez J, Blasco M, Navarro D. Journal of Medical Virology. 2022 Jan;94(1):222-228. doi: 10.1002/jmv.27300. PMID: 34449894

Serum vascular endothelial growth factor b and metabolic syndrome incidence in the population based cohort Di@bet.es study. Lago-Sampedro A, Lhamyani S, Valdes S, Colomo N, Maldonado-Araque C, Gonzalez-Molero I, Doulatram-Gamgaram V, Delgado E, Chaves F, Castano L, Calle-Pascual A, Franch-Nadal J, Rojo-Martinez G, Garcia-Serrano S, Garcia-Escobar E. International Journal of Obesity. 2022 Nov;46(11):2013-2020. doi: 10.1038/s41366-022-01212-1. PMID: 35987953

Structural investigations on novel non-nucleoside inhibitors of human norovirus polymerase. Giancotti G, Nannetti G, Padalino G, Landini M, Santos-Ferreira N, Van Dycke J, Naccarato V, Patel U, Silvestri R, Neyts J, Gozalbo-Rovira R, Rodriguez-Diaz J, Rocha-Pereira J, Brancale A, Ferla S, Bassetto M. Viruses. 2022 Dec 27;15(1):74. doi: 10.3390/v15010074. PMID: 36680114

The role of histo-blood group antigens and microbiota in human norovirus replication in zebrafish larvae. Cuvry A, Gozalbo-Rovira R, Strubbe D, Neyts J, de Witte P, Rodriguez-Diaz J, Rocha-Pereira J. Microbiology Spectrum. 2022 Dec 21;10(6):e0315722. doi: 10.1128/spectrum.03157-22. PMID: 36314930

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation. Ginex T, Marco-Marín C, Wieczór M, Mata CP, Krieger J, Ruiz-Rodriguez P, López-Redondo ML, Francés-Gómez C, Melero R, Sánchez-Sorzano CÓ, Martínez M, Gougeard N, Forcada-Nadal A, Zamora-Caballero S, Gozalbo-Rovira R, Sanz-Frasquet C, Arranz R, Bravo J, Rubio V, Marina A, Geller R, Comas I, Gil C, Coscolla M, Orozco M, Llácer JL, Carazo JM. PLoS Pathogens. 2022 Jul 11;18(7):e1010631. doi: 10.1371/journal.ppat.1010631. PMID: 35816514

Adaptive immune responses to SARS-CoV-2 in recovered severe COVID-19 patients. Olea B, Albert E, Torres I, Amat P, Remigia M, Gozalbo-Rovira R, Rodriguez-Diaz J, Buesa J, Blasco M, Redon J, Signes-Costa J, Navarro D. Journal of Clinical Virology. 2021 Sep;142:104943. doi: 10.1016/j.jcv.2021.104943. PMID: 34391981

Association between long term exposure to particulate matter and incident hypertension in Spain. Doulatram-Gamgaram V, Valdes S, Maldonado-Araque C, Lago-Sampedro A, Badia-Guillen R, Garcia-Escobar E, Garcia-Serrano S, Garcia-Vivanco M, Garrido JL, Theobald MR, Gil V, Martin-Llorente F, Calle-Pascual A, Bordiu E, Castano L, Delgado E, Franch-Nadal J, Chaves FJ, Montanya E, Galan-Garcia JL, Aguilera-Venegas G, Soriguer F, Rojo-Martinez G. Scientific Reports. 2021 Oct 5;11(1):19702. doi: 10.1038/s41598-021-99154-7. PMID: 34611240

Benchmarking different approaches for Norovirus genome assembly in metagenome samples. Fuentes-Trillo A, Monzo C, Manzano I, Santiso-Bellon C, da Silva Ribeiro de Andrade J, Gozalbo-Rovira R, Garcia-Garcia AB, Rodriguez-Diaz J, Chaves FJ. BMC Genomics. 2021 Nov 24;22(1):849. doi: 10.1186/s12864-021-08067-2. PMID: 34819031

Diversity and dynamic changes of Anelloviruses in plasma following Allogeneic Hematopoietic Stem Cell Transplantation. Gimenez Quiles E, Monzo Cataluña C, Albert Vicent E, Fuentes Trillo A, Seda García E, Pinana J, Hernandez Boluda J, Solano Vercet C, Chaves Martínez F, Navarro Ortega D. Journal of Medical Virology. 2021 Aug;93(8):5167-5172. doi: 10.1002/jmv.26661. PMID: 33174620

Epidemiological and Genetic Characterization of Sapovirus in Patients with Acute Gastroenteritis in Valencia (Spain). de Oliveira-Tozetto S, Santiso-Bellon C, Ferrer-Chirivella J, Navarro-Lleo N, Vila-Vicent S, Rodriguez-Diaz J, Buesa J. Viruses. 2021 Jan 26;13(2):184. doi: 10.3390/v13020184. PMID: 33530573

Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study. Garcia-Escobar E, Valdes S, Soriguer F, Vendrell J, Urrutia-Etxebarria I, Maldonado-Araque C, Ortega E, Ocon P, Montanya E, Menendez E, Lago-Sampedro A, Gonzalez-Frutos T, Gomis R, Goday A, Garcia-Serrano S, Galan-Garcia J, Castell C, Bordiu E, Badia R, Aguilera-Venegas G, Girbes J, Gaztambide S, Delgado E, Chaves F, Castano L, Calle-Pascual A, Rojo-Martinez G, Franch-Nadal J. Scientific Reports. 2021 Aug 12;11(1):16453. doi: 10.1038/s41598-021-95546-x. PMID: 34385479

Infant gut microbiota modulation by human milk disaccharides in humanized microbiome mice. Rubio-Del-Campo A, Gozalbo-Rovira R, Moya-Gonzalvez E, Alberola J, Rodriguez-Diaz J, Yebra M. Gut Microbes. 2021 Jan-Dec;13(1):1-20. doi: 10.1080/19490976.2021.1914377. PMID: 33938391

Infant-gut associated Bifidobacterium dentium strains utilize the galactose moiety and release lacto-N-triose from the human milk oligosaccharides lacto-N-tetraose and lacto-N-neotetraose. Moya-Gonzalvez E, Rubio-del-Campo A, Rodriguez-Diaz J, Yebra M. Scientific Reports. 2021 Dec 2;11(1):23328. doi: 10.1038/s41598-021-02741-x. PMID: 34857830

Inference of SARS-CoV-2 spike-binding neutralizing antibody titers in sera from hospitalized COVID-19 patients by using commercial enzyme and chemiluminescent immunoassays. Valdivia A, Torres I, Latorre V, Frances-Gomez C, Albert E, Gozalbo-Rovira R, Alcaraz M, Buesa J, Rodriguez-Diaz J, Geller R, Navarro D. European Journal of Clinical Microbiology & Infectious Diseases. 2021 Mar;40(3):485-494. doi: 10.1007/s10096-020-04128-8. PMID: 33404891

Interaction of Intestinal Bacteria with Human Rotavirus during Infection in Children. Gozalbo-Rovira R, Rubio-Del-Campo A, Santiso-Bellon C, Vila-Vicent S, Buesa J, Delgado S, Molinero N, Margolles A, Yebra M, Collado M, Monedero V, Rodriguez-Diaz J. International Journal of Molecular Sciences. 2021 Jan 20;22(3):1010. doi: 10.3390/ijms22031010. PMID: 33498321

Iodine Deficiency and Mortality in Spanish Adults. Di@bet.es study. Maldonado-Araque C, Valdes S, Badia-Guillen R, Lago-Sampedro A, Colomo N, Garcia-Fuentes E, Gutierrez-Repiso C, Goday-Arno A, Calle-Pascual A, Castano L, Castell C, Delgado Alvarez E, Menendez Torre E, Franch-Nadal J, Gaztambide S, Girbes J, Chaves Martínez F, Soriguer F, Rojo-Martinez G. Thyroid. 2021 Jan;31(1):106-114. doi: 10.1089/thy.2020.0131. PMID: 32781944

Lower respiratory tract and plasma SARS-CoV-2 RNA load in critically ill adult COVID-19 patients: Relationship with biomarkers of disease severity. Olea B, Albert E, Torres I, Gozalbo-Rovira R, Carbonell N, Ferreres J, Poujois S, Costa R, Colomina J, Rodriguez J, Blasco M, Navarro D. Journal of Infection. 2021 Sep;83(3):381-412. doi: 10.1016/j.jinf.2021.05.036. PMID: 34087349

Microbiota depletion promotes human rotavirus replication in an adult mouse model. Gozalbo-Rovira R, Santiso-Bellon C, Buesa J, Rubio-del-Campo A, Vila-Vicent S, Munoz C, Yebra M, Monedero V, Rodriguez-Diaz J. Biomedicines. 2021 Jul 20;9(7):846. doi: 10.3390/biomedicines9070846. PMID: 34356911

Recommendations for the introduction of metagenomic high-throughput sequencing in clinical virology, part I: Wet lab procedure. Lopez-Labrador F, Brown J, Fischer N, Harvala H, Van Boheemen S, Cinek O, Sayiner A, Madsen T, Auvinen E, Kufner V, Huber M, Rodriguez C, Jonges M, Honemann M, Susi P, Sousa H, Klapper P, Perez-Cataluna A, Hernandez M, Molenkamp R, der Hoek L, Schuurman R, Couto N, Leuzinger K, Simmonds P, Beer M, Hoper D, Kamminga S, Feltkamp M, Rodriguez-Diaz J, Keyaerts E, Nielsen X, Puchhammer-Stockl E, Kroes A, Buesa J, Breuer J, Claas E, de Vries J, ESCV Network on Next-Generation Sequencing. Journal of Clinical Virology. 2021 Jan;134:104691. doi: 10.1016/j.jcv.2020.104691. PMID: 33278791

Suitability of Two Rapid Lateral Flow Immunochromatographic Assays for Predicting SARS-CoV-2 Neutralizing Activity of Sera. Valdivia A, Torres I, Latorre V, Frances-Gomez C, Ferrer J, Forque L, Costa R, de la Asuncion C, Huntley D, Gozalbo-Rovira R, Buesa J, Gimenez E, Rodriguez-Diaz J, Geller R, Navarro D. Journal of Medical Virology. 2021 Apr;93(4):2301-2306. doi: 10.1002/jmv.26697. PMID: 33236799

The role of host glycobiology and gut microbiota in rotavirus and norovirus infection, an update. Peña-Gil N, Santiso-Bellón C, Gozalbo-Rovira R, Buesa J, Monedero V, Rodríguez-Díaz J. International Journal of Molecular Sciences. 2021 Dec 15;22(24):13473. doi: 10.3390/ijms222413473. PMID: 34948268

The Rotavirus Vaccine Landscape, an Update. Carcamo-Calvo R, Munoz C, Buesa J, Rodriguez-Diaz J, Gozalbo-Rovira R. Pathogens. 2021 Apr 26;10(5):520. doi: 10.3390/pathogens10050520. PMID: 33925924

Thyroid hormone resistance index and mortality in euthyroid subjects: Di@bet.es study. Alonso SP, Valdes S, Maldonado-Araque C, Lago A, Ocon P, Calle A, Castano L, Delgado E, Menendez E, Franch-Nadal J, Gaztambide S, Girbes J, Chaves F, Garcia-Serrano S, Garcia-Escobar E, Fernandez-Garcia JC, Olveira G, Colomo N, Rojo-Martinez G. European Journal of Endocrinology. 2021 Dec 1;186(1):95-103. doi: 10.1530/EJE-21-0640. PMID: 34735370

Urinary exosomal miR-146a as a marker of albuminuria, activity changes and disease flares in lupus nephritis. Perez Hernandez J, Martínez Arroyo O, Ortega Gutiérrez A, Galera Martos M, Solis Salguero M, Chaves Martínez F, Redón Mas J, Forner Giner M, Cortés Vergaz R. Journal Of Nephrology. 2021 Aug;34(4):1157-1167. doi: 10.1007/s40620-020-00832-y. PMID: 32803682

Urinary- and Plasma-Derived Exosomes Reveal a Distinct MicroRNA Signature Associated With Albuminuria in Hypertension. Perez-Hernandez J, Riffo-Campos A, Ortega A, Martinez-Arroyo O, Perez-Gil D, Olivares D, Solaz E, Martinez F, Martinez-Hervas S, Chaves F, Redon J, Cortes R. Hypertension. 2021 Mar 3;77(3):960-971. doi: 10.1161/HYPERTENSIONAHA.120.16598. PMID: 33486986

Projects
Reference: AICO/2021/033
Title: Role of host mucosal glycosylation in SARS-CoV-2 infectivity 
Funding body: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital
Principal Investigator: Jesús Rodríguez Díaz
Duration: 2022 – 2024
Total budget: 90.000 €
Reference: PI21/00506
Title: Estudio multifactorial para la identificación de nuevos factores genéticos y no genéticos mediante la secuenciación del exoma y técnicas de inteligencia artificial
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Javier Chaves Martínez
Duration: 2022 – 2024
Total budget: 183.920 €
Reference: PMP21/00076
Title: ImpactT2D: una estrategia genómica para implementar medicina de precisión en la diabetes tipo 2
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Javier Chaves Martínez
Duration: 2022 – 2025
Total budget: 106.700 €
Reference: PID2020-115403RB-C22
Title: Glicosil hidrolasas bacterianas y su función en la infectividad viral
Funding body: Ministerio de Ciencia e Innovación
Principal Investigator: Jesús Rodríguez Díaz
Duration: 2021 – 2024
Total budget: 160.930 €
Reference: COV20/00279
Title: Detección y caracterización rápida de COVID19 y del paciente
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Javier Chaves Martínez
Duration: 2020 – 2021
Total budget: 175.000 €
Reference: AEST/2020/041 
Title: Desarrollo de un sistema rápido y económico para la detección de patógenos causantes de gastroenteritis infecciosas mediante EOSAL
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: Jesús Rodríguez Díaz
Duration: 2020 – 2021
Total budget: 40000
Reference: IDIFEDER/2018/056
Title: Creació d’una infraestructura de producció, purificació i caracterització de proteïnes d’interés biomèdic i biotecnològic
Funding body: Conselleria de Educación, Cultura y Deporte
Principal Investigator: Jesús Rodríguez Díaz
Duration: 2018 – 2020
Total budget: 431.414 €
Reference: AGL2017-84165-C2-2-R
Title: Descifrando las interacciones entre la microbiota intestinal/virus entéricos/hospedador: bases para proteger frente a la diarrea viral
Funding body: Ministerio de Economía y Competitividad
Principal Investigator: Jesús Rodríguez Díaz
Duration: 2018 – 2021
Total budget: 133.100 €
Reference: PI17/00544
Title: Identificación de variantes genéticas protectoras frente al desarrollo de diabetes tipo 2 en octogenarios
Funding body: Instituto de Salud Carlos III – Cofinanciado FEDER
Principal Investigator: Felipe Javier Chaves Martínez
Duration: 2018 – 2021
Total budget: 196.020 €
+ Info
Company: Seqplexing
Starting year: 2013
Researchers: Chaves Martínez, Felipe Javier
Web: https://www.seqplexing.com/

Title: Development of bioinformatics tools for the characterization of B cell neoplasms
Doctoral candidate: Fuentes Trillo, Azahara Maria
Director(s): Chaves Martínez, Felipe Javier; Navarro Cubells, Blanca; Terol Casterá, María José
Date of the defense: 10/03/2023
University: Universitat de València

Title: Mgviz: desarrollo e integración de métodos de análisis y visualización de datos genómicos en biomedicina
Doctoral candidate: Juanes Tebar, Jose Miguel
Director(s): Chaves Martínez, Felipe Javier; Marín García, Pablo; Arnau Llombart, Vicente
Date of the defense: 22/03/2021
University: Universitat de València

Title: Aproximaciones moleculares al estudio de las interacciones de rotavirus y norovirus con el huésped
Doctoral candidate: Vila Vicent, Susana
Director(s): Rodríguez Díaz, Jesús; Buesa Gómez, Francisco Javier
Date of the defense: 05/11/2020
University: Universitat de València

Title: Identificación de variantes genéticas relacionadas con diabetes mellitus tipo 2 en población española
Doctoral candidate: Lendínez Tortajada, Verónica
Director(s): Chaves Martínez, Felipe Javier; Real Collado, Jose Tomás
Date of the defense: 31/01/2020
University: Universitat de València

Title: Exome sequencing in gastrointestinal food allergy induced by multiple food protein
Doctoral candidate: Sanchis Juan, Alba
Director(s): Chaves Martínez, Felipe Javier; Marín García, Pablo; García García, Ana-Bárbara; Gadea Vacas, José
Date of the defense: 10/12/2019
University: Universitat Politècnica de València